Perineural Injection Therapy
Targeted nerve nourishment to calm pain and restore function
Perineural Injection Therapy (PIT), also known as neurofascial or perineural dextrose therapy, is a gentle and highly effective treatment that targets superficial sensory nerves contributing to chronic pain. Using a fine needle and a dilute solution of 5% dextrose, the injections are placed just under the skin (not into the muscle or joint) around tender, inflamed, or sensitized nerves.
This therapy works by calming neurogenic inflammation, the type of inflammation caused by nerve irritation, and restoring normal function to nerves involved in persistent pain, tingling, burning, or hypersensitivity. Many patients experience rapid relief and a sense of "nerve quieting" within minutes or hours.​
These entrapments are often missed or underdiagnosed, and nerve hydrodissection offers a safe, non-surgical pathway to both diagnosis and relief.
Frequently Asked Questions (FAQ):
What is the difference between PIT and nerve hydrodissection?
Perineural injection therapy is a superficial technique aimed at calming irritated sensory nerves in the skin and fascia. Hydrodissection is deeper, designed to physically free nerves from compression. Both are powerful, but perineural is especially useful for superficial nerve pain.
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Is this similar to a cortisone shot?
Not at all. There are no steroids involved. The dextrose solution gently nourishes nerves and resets pain signaling without suppressing your body’s healing response.
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How soon will I feel relief?
Many patients feel improvement within minutes to hours. However, long-term resolution usually takes a series of treatments, typically 3 to 6 sessions spaced 1–2 weeks apart.
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Is it safe?
Yes. 5% dextrose is a naturally occurring sugar in the body, and when used properly, it has a very low risk profile. The injections are shallow, making them among the safest injection treatments available.
Perinerual Injection Therapy Post-Procedure Care Guidelines:
Activity:
You can resume most normal activities the same day. Avoid strenuous activity for 24 hours.
Symptoms:
You might feel some mild achiness or tightness over the injection sites. This is temporary and normal.
Hydration:
Stay well-hydrated and consider gentle stretching to support the nervous system reset.
Tracking Relief:
Keep notes on changes in pain, burning, numbness, or sensitivity, this helps tailor your treatment.